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RiboParser documentation

RiboParser is a modular command-line toolkit for comprehensive RNA-seq and Ribo-seq data analysis.

This documentation keeps the repository README short and moves the complete tutorial, parameter explanations, command templates, output interpretation, and helper scripts into a structured website.

Complete workflow

Reference preparation
→ Raw data download
→ Raw data cleaning
→ Alignment and quantification
→ Quality control
→ Gene-level analysis
→ Codon-level analysis
→ smORF analysis
→ SeRP analysis
→ Visualization and downstream analysis

Main command groups

Group Commands
Ribo-quality rpf_Reference, rpf_Check, rpf_Digest, rpf_Offset, rpf_Density, rpf_Merge, rpf_Periodicity, rpf_Metaplot, rpf_Coverage, rpf_Corr, rpf_Quant, rpf_Percent
RNA rna_Offset, rna_Density
Ribo-pausing rpf_Pausing, rpf_Occupancy, rpf_CoV, rpf_Cumulative_CoV, rpf_CDT, rpf_CST, rpf_Odd_Ratio, rpf_Meta_Codon
Ribo-utils rpf_Shuffle, rpf_Shift, rpf_Retrieve, rpf_Bam2bw, rpf_Geneplot
smORF smorf_scanner, smorf_filter, smorf_evidence, smorf_integrate
SeRP serp_overlap, serp_peak, serp_properties
Helper scripts FASTA, FASTQ, bedGraph, Bowtie, merge_ribo, RiboCode, RiboTISH, RSEM, Unix helpers

Example dataset

The original workflow uses GSE67387 as an example dataset.

Nedialkova DD, Leidel SA.
Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity.
Cell 2015 Jun 18;161(7):1606-18.
PMID: 26052047